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September 2024

Published by The American Journal of Tropical Medicine and Hygiene.
Authors: Valery Madsen Beau De Rochars, Jeannine Coreil, Martha Désir, Gladys Mayard, Marie Carmel Michel, Marie Denise Milord, Rand Carpenter, Thomas G. Streit, Luccène Désir, Gregory S. Noland, and David G. Addiss
Description: Support groups can create environments that are conducive to healing and well-being, particularly for persons with stigmatizing chronic diseases. In 1998, the support group concept was adapted in Haiti for persons with disabling lymphedema caused by lymphatic filariasis (LF). The project was developed with the expectation that the support group model conceived in the developed world be interpreted and modified by persons affected with lymphedema in the Haitian setting. Initiated with modest financial support within a research initiative to eliminate LF, a total of 50 “Hope Clubs” were formed from 1998 to 2023 across seven communes (districts) located in 3 of Haiti’s 10 regional Departments. Documented benefits of the support groups included improved limb self-care, decreased incidence of inflammatory episodes (adenolymphangitis), enhanced self-efficacy, economic benefit through microenterprise, and improved quality of life. Despite challenges of funding shortfalls, natural disasters, and political insecurity, persistence of LF support groups in Haiti highlights the crucial role of group ownership by affected persons and the freedom to reinvent the support group concept in light of local social, cultural, and economic conditions.

September 2024

Published by The American Journal of Tropical Medicine and Hygiene.
Authors : Luccène Désir, Karen E. S. Hamre, Valéry Madsen Beau De Rochars, Jean F. Lemoine, Marc-Aurèle Telfort, and Gregory S. Noland
Description: Haiti is endemic for lymphatic filariasis (LF) and malaria, two mosquito-transmitted parasitic diseases targeted for elimination. The World Health Organization recommends a transmission assessment survey (TAS-1) to determine if LF prevalence is significantly beneath putative transmission thresholds (<2% antigen prevalence in Haiti, where Culex is the primary vector for Wuchereria bancrofti) to stop mass drug administration (MDA). Repeated TASs (TAS-2 and TAS-3) are recommended at 2–3-year intervals during post-treatment surveillance. From 2017 to 2022, The Carter Center assisted the Haitian Ministry of Public Health and Population in conducting 15 TASs in 11 evaluation units (EUs) encompassing 54 of the country’s 146 districts. Children 6–7 years old were assessed for circulating filarial antigen (CFA) by Filariasis Test Strip: n = 5,239 in TAS-1; n = 11,866 in TAS-2; and n = 1,842 in TAS-3, of whom eight (0.15%), 20 (0.17%), and eight (0.43%) tested positive, respectively. The number of positive results in children was less than the threshold in each EU. When available, participants (n = 16,663) were also tested for malaria by rapid diagnostic test, with 31 (0.19%) children testing positive for Plasmodium falciparum. Integrated TASs provided an efficient means to collect epidemiological data for LF and malaria in Haiti. Results indicated thresholds for stopping and maintaining the halt of MDA for LF have been achieved in all EUs, with the halt of MDA for 571,358 people in four districts and the first TAS-3 surveys conducted in Haiti. Investigations are needed to assess the potential of ongoing LF transmission, especially in areas where CFA-positive samples were detected in TAS-3.

September 2024

Published by The American Journal of Tropical Medicine and Hygiene.
Authors: Jenna E. Coalson, Gregory S. Noland, Andrew W. Nute, Erica Brook Goodhew, Diana L. Martin, Zeinab Abdalla, Isam Zarroug, Soheir Gabralla, Hassan Ahmed Hassan Ahmed Ismail, William Evan Secor, Elizabeth Kelly Callahan, Angelia M. Sanders, Balgesa Elshafie, and Scott D. Nash
Description: Sudan is endemic for multiple neglected tropical diseases, including trachoma, onchocerciasis (OV), lymphatic filariasis (LF), and schistosomiasis (SCH). In 2019, dried blood spot samples were collected for a baseline trachoma serosurvey in three localities (El Seraif, Kotom, and Saraf Omrah) in North Darfur State. None were classified previously as OV- or LF-endemic, although low levels of SCH had been identified in all three. Approximately 30 households from 25 communities in each locality were selected by multistage cluster random sampling. Collections of DBSs were analyzed by multiplex bead assay for antibodies to multiple pathogens. This paper presents data on OV (Ov16), LF (Wb123, Bm14, Bm33), and SCH (soluble egg antigen [SEA], Sm25) antibodies among 8,322 individuals from 2,119 households. The survey-adjusted seroprevalence estimates for Ov16 were <0.3% in all localities. Lymphatic filariasis–antigen seroprevalences were discordant. Seroprevalence estimates ranged from 4.6–6.0% (Wb123), 0.99–1.4% (Bm14), and 29.2–33.3% (Bm33). Schistosomiasis seroprevalence estimates among school-aged children ranged from 2.7–8.0% (SEA) and 10.9–15.6% (Sm25). Ov16 seropositivity was low and supported the localities’ classification as nonendemic. The results suggested LF exposure, but discordance between antigens, challenges defining seropositivity thresholds, and the absence of programmatic guidance based on antibody serology alone for Wuchereria bancrofti indicate a need for remapping surveys to confirm transmission. Schistosomiasis antibody levels were high enough to warrant further mapping to guide treatment decisions. The lack of gold standards limited interpretation of results, particularly for LF, but in resource-challenged areas, integrated serological surveillance offers the possibility of efficient monitoring of exposure to multiple diseases.

March 2024
A Pilot Study to Address the Mental Health of Persons Living With Lymphatic Filariasis in Léogâne, Haiti: Implementing a Chronic Disease Self-Management Program Using a Stepped-Wedge Cluster Design (PDF)
Published by . doi.org/10.1093/inthealth/ihae006
Authors: Shanze Sadiq, Karen E S Hamre, Samhita Kumar, Sarah Bazur-Leidy, Luccène Désir, M Martha Désir, Murielle C Gilbert, V Madsen Beau de Rochars, Marc-Aurèle Telfort, Gregory S Noland, Eve Byrd.
This paper presents a pilot study to assess the effectiveness of a chronic disease self-management program (CDSMP) that was introduced to lymphatic filariasis peer support groups in Léogâne, Haiti. We used household surveys at baseline and endpoint to measure self-rated health, depression, disease self-efficacy, perceived social support, and quality of life.

Oct. 4, 2023
A Tribute to the Global Health Legacy of Jimmy and Rosalynn Carter (PDF)
Published by The American Journal of Tropical Medicine and Hygiene; 109(4), 2023, pp. 713–714 doi:10.4269/ajtmh.23-0641.
Authors: Kashef Ijaz and Julie Jacobson.
Abstract: The global public health legacy of former U.S. President Jimmy Carter and First Lady Rosalynn Carter cannot be overstated. For more than 50 years, they have leveraged the power of their characters and connections to advance public health in the United States and around the world.

July 29, 2020
The Role of Non-Governmental Development Organizations in the Implementation of Lymphatic Filariasis Programmes (PDF)
Published by The Royal Society of Tropical Medicine and Hygiene.
Authors: Simon Bush, Frank O. Richards, Jr., and Yaobi Zhang
The Lymphatic Filariasis (LF) Non-governmental Development Organization (NGDO) Network was established to engage in supporting both international and national LF elimination agendas covering areas such as assisting ministries of health as an on-the-ground link between communities and programmes, which additionally gives the Network members an important voice from the field at international meetings; playing key roles in programme evolution (especially helping to both scale up and scale down mass drug administration [MDA] as elimination thresholds are met); having a role in operational research and developing new programme delivery models that can be taken to scale (such as linkages with other disease programmes and approaches to morbidity management and disability prevention); developing advocacy and policy approaches with other partners; convening other important stakeholders (academic, technical, programmatic and funding); mobilizing financial and technical resources to support programmes; supporting national human resource capacity building to catalyse national ownership of LF programmes; providing leadership in LF governance structures and working in areas of conflict to ensure that everybody in LF-endemic areas enjoys treatment services.

July 21, 2020
Predicting Lymphatic Filariasis Elimination in Data-Limited settings: A Reconstructive Computational Framework for Combining Data Generation and Model Discover (PDF)
Published by PLOS Computational Biology.
Authors: Morgan E. Smith, Emily Griswold, Brajendra K. Singh, Emmanuel Miri, Abel Eigege, Solomon Adelamo, John Umaru, Kenrick Nwodu, Yohanna Sambo, Jonathan Kadimbo, Jacob Danyobi, Frank O. Richards, Jr., Edwin Michael
Although there is increasing importance placed on the use of mathematical models for the effective design and management of long-term parasite elimination, it is becoming clear that transmission models are most useful when they reflect the processes pertaining to local infection dynamics as opposed to generalized dynamics. Such localized models must also be developed even when the data required for characterizing local transmission processes are limited or incomplete, as is often the case for neglected tropical diseases, including the disease system studied in this work, viz. lymphatic filariasis (LF).

May 29, 2020

Published by PLOS Neglected Tropical Diseases.
Authors: Breanna K. Wodnik , Didié Hérold Louis, Michel Joseph, Lee T. Wilkers, Susan D. Landskroener, Luccene Desir, Jean Frantz Lemoine, James V. Lavery
The World Health Organization (WHO) defines an effective round of mass drug administration (MDA) for lymphatic filariasis (LF) as one that reaches at least 65% of the target population. In its first round of MDA in 2011–2012, the National Program to Eliminate LF in Haiti achieved a 79% epidemiological coverage in urban Port-au-Prince.

March 30, 2020
Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys (PDF)
Published by The American Journal of Tropical Medicine and Hygiene.
Authors: Abel Eigege, Gregory S. Noland, Solomon E. Adelamo, Kenrick Nwodu, Adamu Sallau, John Umaru, Bulus S. Mancha, Emmanuel Davies, Jacob Danboyi, Jonathan A. Kadimbo, Yisa A. Saka, Ifeoma Anagbogu, Emmanuel S. Miri, and Frank O. Richards, Jr.
Following the halt of mass drug administration (MDA) for lymphatic filariasis (LF), the WHO recommends at least 4 years of post-treatment surveillance (PTS) to confirm that transmission recrudescence or importation does not occur. The primary means of evaluation during PTS is repeated transmission assessment surveys (TASs) conducted at 2- to 3-year intervals after TAS-1 stop-MDA surveys.

Nov 19, 2018
Substantiating Freedom from Parasitic Infection by Combining Transmission Model Predictions with Disease Surveys (PDF)
Published by Nature Communications.
Authors: Edwin Michael, Morgan E. Smith, Moses N. Katabarwa, Edson Byamukama, Emily Griswold, Peace Habomugisha, Thomson Lakwo, Edridah Tukahebwa, Emmanuel S. Miri, Abel Eigege, Evelyn Ngige, Thomas R. Unnasch and Frank O. Richards, Jr.
Stopping interventions is a critical decision for parasite elimination programmes. Quantifying the probability that elimination has occurred due to interventions can be facilitated by combining infection status information from parasitological surveys with extinction thresholds predicted by parasite transmission models. Here we demonstrate how the integrated use of these two pieces of information derived from infection monitoring data can be used to develop an analytic framework for guiding the making of defensible decisions to stop interventions.

June 21, 2018
Evaluation of Treatment Coverage and Enhanced Mass Drug Administration for Onchocerciasis and Lymphatic Filariasis in Five Local Government Areas Treating Twice Per Year in Edo State, Nigeria (PDF)
Published by The American Journal of Tropical Medicine and Hygiene.
Authors: Emily Griswold, Abel Eigege, Cephas Ityonzughul, Emmanuel Emukah, Emmanuel S. Miri, Ifeoma Anagbogu, Yisa A. Saka, Saliu Kadiri, Solomon Adelamo, Paul Ugbadamu, Clement Ikogho, and Frank O. Richards, Jr.
The western region of Edo state in southern Nigeria is highly endemic for onchocerciasis. Despite years of mass drug administration (MDA) with ivermectin (IVM), reports suggest persistently high prevalence of onchocerciasis, presumably because of poor coverage. In 2016, twice-per-year treatment with IVM (combined with albendazole for lymphatic filariasis in the first round where needed) began in five local government areas (LGAs) of Edo state.

June 2018
Building Trust through Lymphatic Filariasis Elimination: A Platform to Address Social Exclusion and Human Rights in the Dominican Republic
Published by Health and Human Rights Journal, Volume 20, Issue 1, June 2018.
Authors: Hunter Keys, Manuel Gonzales, Madsen Beau de Rochars, Stephen Blount, and Gregory S. Noland.
Hispaniola, the Caribbean island that includes the countries of Haiti and the Dominican Republic (DR), accounts for 90% of lymphatic filariasis (LF) in the Americas. Both countries have committed to LF elimination by 2020. In the DR, LF occurs mainly in bateyes, or company towns that historically hosted migrant laborers from Haiti. A legacy of anti-Haitian discrimination as well as the 2013 Sentencia, which stripped generations of Haitian-descended Dominicans of their citizenship, ensure that this population remains legally, economically, and socially marginalized. Despite this context, the country’s LF elimination program (PELF) has worked in bateyes to eliminate LF through health education and annual drug treatment to interrupt parasite transmission.

June 2018
Emotional Difficulties and Experiences of Stigma among Persons with Lymphatic Filariasis in Plateau State, Nigeria
Published by Health and Human Rights Journal, Volume 20, Issue 1, June 2018.
Authors: Jibril Abdulmalik, Emeka Nwefoh, James Obindo, Samuel Dakwak, Motunrayo Ayobola, John Umaru, Elisha Samuel, Christopher Ogoshi, and Julian Eaton.
Lymphatic filariasis (LF) is a chronic and often disfiguring condition that predominantly affects the rural poor and leads to social exclusion, stigma, and discrimination. Little is currently known about the emotional difficulties and stigma experiences among persons living with LF in Nigeria. Our study evaluated the emotional difficulties and stigma experienced by persons with LF in Plateau State, Nigeria. We utilized a combination of qualitative data instruments comprising focus group discussions, McGill’s Illness Narrative Interviews, and key informant interviews. We transcribed and analyzed the data using a combination of inductive and deductive coding approaches. Sixtynine respondents were interviewed: 37 females and 32 males. The prevalent community perception of LF was the belief that it was a spiritual problem.

Nov. 23, 2017

Published by New England Journal of Medicine, 377:2088-2090.
Author: Frank O. Richards, Jr.
An innovative cell-phone–based device (the LoaScope) was used to rapidly identify persons with very high L. loa microfilariae counts (>20,000 mf per milliliter) and exclude them from ivermectin treatment. In a district in Cameroon where L. loa infection is highly endemic, more than 16,000 participants were tested with the LoaScope; testing led to the identification of 340 persons at high risk for serious adverse events and their exclusion from ivermectin treatment. Proper use of the LoaScope cell-phone device can help avoid adverse reactions to ivermectin in areas where Loa loa infection is known to exist.

Sept. 1, 2017
Criteria to Stop Mass Drug Administration for Lymphatic Filariasis Have Been Achieved Throughout Plateau and Nasarawa States, Nigeria
Published by American Journal of Tropical Medicine and Hygiene, 97(3), 2017, pp. 677–680 doi:10.4269/ajtmh.16-0843.
Authors: Abel Eigege, Darin S. Evans, Gregory S. Noland, Emmanuel Davies, John Umaru, Solomon E. Adelamo, Bulus Mancha, Jonathan D. King, Emmanuel S. Miri, Bridget Okoeguale, Emily P. Griswold, and Frank O. Richards, Jr.
Nigeria has the largest population at risk for lymphatic filariasis (LF) in Africa. This study used a transmission assessment survey (TAS) to determine whether mass drug administration (MDA) for LF could stop in 21 districts, divided into four evaluation units (EUs), of Plateau and Nasarawa States, Nigeria, after 8–12 years of annual albendazole–ivermectin treatment.

June 1, 2017
Prevalence of Depression and Associated Clinical and Socio-Demographic Factors in People Living with Lymphatic Filariasis in Plateau State, Nigeria (PDF)
Published by PLOS Neglected Tropical Diseases.
Authors: James Obindo, Jibril Abdulmalik, Emeka Nwefoh, Michael Agbir, Charles Nwoga, Aishatu Armiya’u, Francis Davou, Kurkat Maigida, Emmanuel Otache, Ajuma Ebiloma, Samuel Dakwak, John Umaru, Elisha Samuel, Christopher Ogoshi, Julian Eaton
Lymphatic filariasis is a chronic, disabling and often disfiguring condition that principally impacts the world’s poorest people. In addition to the well-recognised physical disability associated with lymphedema and hydrocele, affected people often experience rejection, stigma and discrimination. The resulting emotional consequences are known to impact on the quality of life and the functioning of the affected individuals

Dec. 6, 2016

Published by CNN.
Authors: Mary Ann Peters and Sue Desmond-Hellmann 
The first thing you notice about Jude is his playful spirit and insatiable curiosity. An inquisitive and talented 13-year-old boy in Nigeria, Jude loves going to school, practicing drums and playing soccer with his friends. He dreams of growing up to serve his community and nation. Last week, Ambassador Peters was with Jude as he received a handful of small pills: the 500 millionth treatment the Carter Center has given across Africa and Latin America to stop diseases that blind, stunt development and rob people of nutrients. The story behind treatments to stop tropical diseases like these, and how they come to improve the lives of so many, is a remarkable public health success that few people know anything about.

May 30, 2015 
Published by The Lancet.
Authors: Darin S. Evans, Thomas R. Unnasch, Frank O. Richards, Jr.
About 164 million Africans are at risk of onchocerciasis, and for more than two decades, mass drug administration with ivermectin has been the primary drug to control it.1 In 2010, WHO and the World Bank African Programme for Onchocerciasis Control (APOC) announced a strategic transition from onchocerciasis morbidity control to Onchocerca volvulus transmission elimination and set an elimination goal of 2025 for most of Africa.

Sept. 18, 2014

Published by PLoS Neglected Tropical Diseases, 8(9): e3113. doi:10.1371/journal.pntd.0003113.
Authors: Darin S. Evans, Kal Alphonsus, Jon Umaru, Abel Eigege, Emmanuel Miri, Hayward Mafuyai, Carlos Gonzales-Peralta, William Adamani, Elias Pede, Christopher Umbugadu, Yisa Saka, Bridget Okoeguale, Frank O. Richards, Jr.
Both lymphatic filariasis and onchocerciasis are treated with ivermectin-based mass drug administration (MDA) regimens in Africa. Where the infections are co-endemic, ivermectin treatments cannot be stopped until both infection transmission cycles are broken. This report follows a previous determination that the LF transmission cycle had been interrupted in five districts (LGAs in Nigeria) but evidence was needed on the status of the onchocerciasis transmission cycle prior to halting MDA.

Oct. 31, 2013
Long-Lasting Insecticidal Nets Are Synergistic with Mass Drug Administration for Interruption of Lymphatic Filariasis Transmission in Nigeria (PDF)
Published by PLoS Journal of Neglected Tropical Diseases. 7(10): e2508. doi:10.1371/journal.pntd.0002508. Reprinted with permission.
Authors: Abel Eigege, Alphonsus Kal, Emmanuel Miri, Adamu Sallau, John Umaru, Hayward Mafuyai, Yohanna S. Chuwang, Goshit Danjuma, Jacob Danboyi, Solomon E. Adelamo, Bulus S. Mancha, Bridget Okoeguale, Amy E. Patterson, Lindsay Rakers*, Frank O. Richards, Jr.
In Plateau and Nasarawa states in central Nigeria, 4 million persons are threatened by a mosquito-transmitted parasitic disease called lymphatic filariasis (LF). LF can lead to elephantiasis, a crippling condition in which the limbs and genitals often are grotesquely swollen or enlarged. Through health education and community-delivered mass drug administration (MDA) with donated medicines, the Nigerian Ministry of Health and its Carter Center partners have been trying to stop mosquitoes from transmitting LF.

Aug. 12, 2013

Published by The American Journal of Tropical Medicine and Hygiene, 2013, 89(3): 578–587, doi: 10.4269/ajtmh.13-0775.
Authors: Frank O. Richards, Jr., Emmanuel Emukah, Patricia M. Graves, Omeni Nkwocha, Lawrence Nwankwo, Lindsay Rakers, Aryc Mosher, Amy Patterson, Masayo Ozaki, Bertram E. B. Nwoke, Chinyere N. Ukaga, Chidiebere Njoku, Kenrick Nwodu, Andrew Obasi, and Emmanuel S. Miri
Lymphatic filariasis (LF) in rural southeastern Nigeria is transmitted mainly by Anopheles spp. mosquitoes. Potential coinfection with Loa loa in this area has prevented use of ivermectin in the mass drug administration (MDA) strategy for LF elimination because of potential severe adverse L. loa-related reactions. This study determined if long-lasting insecticidal net (LLIN) distribution programs for malaria would interrupt LF transmission in such areas, without need for MDA.

Jan. 3, 2013

Published by New England Journal of Medicine, Vol 368 No. 1.pp. 53-64. Doi:10.1056/NEJMra1200391.
Author: Donald R. Hopkins. 
Since the last case of naturally-occurring smallpox in 1977, there have been three major international conferences devoted to the concept of disease eradication. Several other diseases have been considered as potential candidates for eradication, but the World Health Organization (WHO) has targeted only two other diseases for global eradication after smallpox. In 1986, WHO's policy-making body, the World Health Assembly, adopted the elimination of dracunculiasis (Guinea worm disease) as a global goal, and it declared eradication of poliomyelitis a global goal in 1988. Although both diseases now appear to be close to eradication, the fact that neither goal has been achieved after more than two decades, and several years beyond the initial target dates for their eradication, underscores the daunting challenge of such efforts, as does the failure of previous attempts to eradicate malaria, hookworm, yaws and other diseases. "Disease Eradication" was published as part one of "A Global View of Health – An Unfolding Series."

Aug. 1, 2012

Published by the , 87(2), 2012, pp. 272-280. (Login may be required for full text.)
Authors: Jonathan D. King, Abel Eigege, John Umaru, Nimzing Jip, Emmanuel Miri, Jonathan Jiya, Kal M. Alphonsus, Yohanna Sambo, Patricia Graves and Frank O. Richards, Jr.
An average of six annual rounds of ivermectin and albendazole were distributed in Plateau and Nasarawa States, Nigeria, to eliminate lymphatic filariasis. From 2007 to 2008, population-based surveys were implemented in all 30 local government areas (LGAs) of the two states to determine the prevalence of Wuchereria bancrofti antigenemia to assess which LGA mass drug administration (MDA) could be halted.

April 19, 2012

Published by the Emory Report.
Author: Emily Staub
Efforts to eliminate two mosquito-borne diseases – malaria and lymphatic filariasis – in Haiti and the Dominican Republic are ongoing, with the first of four meetings on the issue this year held in Santo Domingo in March.

Feb. 1, 2012

Published by . Reprinted with permission.
Authors: Welelta Shiferaw, Tadesse Kebede, Patricia M. Graves, Lemu Golasa, Teshome Gebre, Aryc W. Mosher, Abiot Tadesse ,Heven Sime, Tariku Lambiyo,K.N. Panicker, Frank O. Richards, Jr., Asrat Hailu
Lymphatic filariasis is known to be endemic in Gambella Region, western Ethiopia, but the full extent of its endemicity in other regions is unknown. A national mapping program for Ethiopia was initiated in 2008. This report summarizes initial data on the prevalence of Wuchereria bancrofti antigenaemia based on surveys carried out in a sampled population of 11 685 individuals living in 125 villages (112 districts) of western Ethiopia.

Oct. 11, 2011
Epidemiological and Entomological Evaluations after Six Years or More of Mass Drug Administration for Lymphatic Filariasis Elimination in Nigeria (PDF)
Published by PLoS Journal of Neglected Tropical Diseases and is reprinted with permission. 5(10): e1346. doi:10.1371/journal.pntd.0001346.
Authors: Richards FO, Eigege A, Miri ES, Kal A, Umaru J, et al. 2011. 
The current strategy for interrupting transmission of lymphatic filariasis (LF) is annual mass drug administration (MDA), at good coverage, for 6 or more years. We describe our programmatic experience delivering the MDA combination of ivermectin and albendazole in Plateau and Nasarawa states in central Nigeria, where LF is caused by anopheline transmitted Wuchereria bancrofti.

March 30, 2010
A Project for Haiti: The Eradication of Two Diseases
Published by The New York Times.
Author: Dr. Donald R. Hopkins
This letter to the editor of the New York Times by Carter Center Vice President for Health Programs, Dr. Donald Hopkins, was written in response to the March 28, 2010 editorial "Making Haiti Whole." Two projects that the donors conference on Haiti should consider this week are the binational plan that Haiti and the Dominican Republic announced last October to eliminate malaria by 2020, and the plan that Haiti announced simultaneously to eliminate lymphatic filariasis (elephantiasis) by 2020 (the Dominican Republic expects to eliminate lymphatic filariasis this year).

Nov. 7, 2008
Published by The American Journal of Tropical Medicine and Hygiene, 2008 80(3), 2009, pp. 447–451.
Authors: Gail Thomas, Frank O. Richards, Jr., Abel Eigege, Nuhu K. Dakum, Martin P. Azzuwut, John Sarki, Ibrahim Gontor, Jacob Abimiku, Gladys Ogah, Munirah Y. Jindau, Jonathan Y. Jiya, and Emmanuel S. Miri.
In a pilot program of mass surgery weeks (MSW) to provide hydrocelectomy services to men with filarial scrotal hydrocele, local general practitioners performed 425 surgical repairs in 301 men in five MSW in three rural Nigerian community hospitals between 2002 and 2005. The most common (94%) procedure used was the eversion technique, which was most familiar to the practitioners. Postoperative complications included hematoma (3.7%) and infection (3%), and there was one death from infection in an elderly man with previously unrecognized diabetes. In 115 patients (38%) followed for 1 to 3 years, the hydrocele recurrence rate was 7%. The eversion technique gives an acceptable outcome, and MSW are safe and effective if strict attention is paid to preoperative screening of candidates and asepsis.

Jan. 1, 2008
Collecting Baseline Information for National Morbidity Alleviation Programs: Different Methods to Estimate Lymphatic Filariasis Morbidity Prevalence (PDF)
Published by Am. J. Trop. Med. Hyg., 78(1), 2008, pp. 153–158, Copyright 91视频 © 2008 by The American Journal of Tropical Medicine and Hygiene.
Authors: Els Mathieu,* Josef Amann, Abel Eigege, Frank O. Richards, Jr., and Yao Sodahlon.
The lymphatic filariasis elimination program aims not only to stop transmission, but also to alleviate morbidity. Although geographically limited morbidity projects exist, few have been implemented nationally. For advocacy and planning, the program coordinators need prevalence estimates that are currently rarely available. This article compares several approaches to estimate morbidity prevalence: (1) data routinely collected during mapping or sentinel site activities; (2) data collected during drug coverage surveys; and (3) alternative surveys. Data were collected in Plateau and Nasarawa States in Nigeria and in 6 districts in Togo.

March 1, 2006

Published by Ann Trop Med Parasitol. Mar 2006: 100(2): 163-172.
Authors: Terranella A, Eigege A, Gontor I, Dagwa P, Damishi S, Miri E, Blackburn B, McFarland D, Zingeser J, Jinadu MY, Richards FO.
Wuchereria bancrofti and the other mosquito-borne parasites that cause human lymphatic filariasis (LF) infect over 120 million people world-wide. Global efforts are underway to stop transmission of the parasites, using annual, single-dose mass drug administrations (MDA) to all at-risk populations.

June 2003

Published by Am J Trop Med Hyg. Jun 2003: 68(6): 643-646.
Authors: Eigege A, Richards F, Blaney D, Miri ES, Gontor I, Ogah G, Umaru J, Jinadu MY, Mathai W, Amadiegwu S, Hopkins DR
The rapid immunochromatographic card test (ICT) for Wuchereria bancrofti circulating filarial antigen is being used to map areas endemic for lymphatic filariasis. However, the ICT is expensive; thus, surveys based on this test must be relatively limited.

Jan. 1, 2002
Lymphatic Filariasis Elimination and Schistosomiasis Control in Combination with Onchocerciasis Control in Nigeria
Published by American Journal of Tropical Medicine and Hygiene. 2002; 67(3):266-72.
Authors: Hopkins D.R., Eigege A., Miri E.S., Gontor, I., Ogah, G., Umaru, J., Gwomkudu, C.C., Mathai, W., Jinadu, M.Y., Amadiegwu, S., Oyenekan, O.K., Korve, K., Richards, F.O. 
This paper describes a pilot initiative to incorporate lymphatic filariasis (LF) elimination and urinary schistosomiasis (SH) control into a mature onchocerciasis control program bsed on community-directed ivermectin treatment in central Nigeria. In the same districts having onchocerciasis we found LF (as determined by blood antigen testing in adult males) in 90% of 149 villages with a mean prevalence of 22.4% (range 0-67%). Similarly, SH, as a mean prevalence in school age children of 24.4% (range 0-87%). Health education and treatment interventions for SH resulted in 52,480 cumulative praziquantel treatments, and 159,555 combined onchocerciasis and LF treatments (with ivermectin and albendazole) as of the end of 2000. Treatments for onchocerciasis and LF were separated by at least 1 week from treatments for SH. There was no negative impact on the coverage of the onchocerciasis program by the addition of LF and SH activities.